The Data Assembly will engage with civil rights organizations, key data holders and policymakers working in the United States, vulnerable groups and the public. This work will be done through remote consultations and deliberative platforms. With a diverse network of stakeholders, we will co-design a responsible data re-use framework. This framework will inform if, when and how the re-use personal data can be aligned with people’s expectations and societal values. While the initial focus of the Data Assembly will be data re-use for COVID-19 measures in New York City, the framework created will be applicable to policymaking beyond this pandemic.